补充omega-3组皮质醇水平更低
图注
先前的研究表明,炎症压力反应较高的人可能伴随更高的抑郁风险,此外,许多慢性病,包括高血压、冠状动脉钙化均表现出过度的皮质醇反应[14]。通过补充omega-3降低炎症反应和压力诱导的皮质醇释放,可能有助于预防慢性疾病和抑郁症,具有重要的临床意义。
不过,该研究的样本主要是受过高等教育的中年超重白人女性,可能需要对不同BMI、不同年龄段、不同种族、以及男性人群的效果进行评估,以进一步确认omega-3补充剂对压力应激相关疾病的影响;同时,本研究仅分析了端粒酶的压力应激变化,未分析相应的疾病标志物端粒长度的变化,也未提供与衰老相关的表观变化,因此,需要更长时间的研究和更全面的数据来确定。
此外,本研究中所使用的是高EPA的omega-3补充剂,这与我们日常接触到的鱼油(通常是高DHA的配方)不同,因此,不同配方的omega-3补充剂(如ALA、不同比例的DHA、EPA的鱼油制剂以及磷虾油等)对不同人群压力应激相关疾病的改善效力值得进一步评估。
参考文献:
[1]Harris WS, Tintle NL, Imamura F, et al. Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies. Nat Commun. 2021;12(1):2329.
[2]Budoff MJ, Bhatt DL, Kinninger A, et al. Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: final results of the EVAPORATE trial. Eur Heart J. 2020;41(40):3925-3932.
[3]Horvath S, Erhart W, Brosch M, Ammerpohl O, von Schönfels W,Ahrens M, et al. Obesity accelerates epigenetic aging of human liver. Proc Natl Acad Sci. 2014;111:15538–43.
[4]Madison AA,Belury MA, Andridge R, et al. Omega-3 supplementation and stress reactivity of cellular aging biomarkers: an ancillary substudy of a randomized, controlled trial in midlife adults [published online ahead of print, 2021 Apr 20]. Mol Psychiatry. 2021;10.1038/s41380-021-01077-2.
[5] Turner AI, Smyth N, Hall SJ, Torres SJ, Hussein M, Jayasinghe SU, et al. Psychological stress reactivity and future health and disease outcomes: a systematic review of prospective evidence. Psychoneuroendocrinology. 2020;114:104599.
[6] Kiecolt-Glaser JK, Renna ME, Shrout MR, Madison AA. Stress reactivity: what pushes us higher, faster, and longer—and why it matters. Curr Dir Psychol Sci. 2020;29:492–8.]
[7]Aschbacher K, Epel E, Wolkowitz O, Prather A, Puterman E, Dhabhar F. Maintenance of a positive outlook during acute stress protects against pro-inflammatory reactivity and future depressive symptoms. Brain Behav Immun. 2012;26:346–52.]
[8] Epel ES, Lin J, Dhabhar FS, Wolkowitz OM, Puterman E, Karan L, et al. Dynamics of telomerase activity in response to acute psychological stress. Brain Behav Immun. 2010;24:531–9.
[9]Codd V, Nelson CP, Albrecht E, Mangino M, Deelen J, Buxton JL, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet. 2013;45:422–7.
[10]Kiecolt-Glaser JK, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, et al. Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: a randomized controlled trial. Brain Behav Immun. 2013;28:16–24.
[11]Kiecolt-Glaser JK, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, et al. Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: a randomized controlled trial. Brain Behav Immun. 2013;28:16–24.
[12] Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Hwang BS, Glaser R. Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: a randomized controlled trial. Brain Behav Immun. 2012;26:988–95.
[13]Ginty AT, Conklin SM. Preliminary evidence that acute long chain omega-3 supplementation reduces cardiovascular reactivity to mental stress: a randomized and placebo controlled trial. Biol Psychol. 2012;89:269–72.
[14] Hamer M, Endrighi R, Venuraju SM, Lahiri A, Steptoe A. Cortisol responses to mental stress and the progression of coronary artery calcification in healthy men and women. PLoS ONE. 2012;7:e31356.
本文作者 | 代丝雨