despite和in spite of是同义词，但是in spite of语气较强。
下面通过大量经典例句学习揣摩，以达到融会贯通，运用自如：
Despite his old age，he is learning to drive.虽然年事已高，他仍然在学驾驶。
Her voice was shaking despite all her efforts to control it.
尽管她竭尽全力控制自己，声音仍然在颤抖。
Despite applying for hundreds of jobs, he is still out of work.
尽管他申请了数百个工作，但仍然在失业中。
She was good at physics despite the fact that she found it boring.
尽管她认为物理枯燥无味，她却学得很好。
Despite a thorough investigation, no trace of Dr Southwell has been found.
尽管进行了彻底的调查，还是没有发现索思韦尔博士的任何踪迹。
Despite her earnest efforts, she could not find a job.
尽管她已尽心竭力，但是仍然找不到工作。
Despite all their efforts to win the game, they were defeated by 4 to 3.
虽然他们竭尽全力想赢得比赛，最后还是以4比3的比分被击败。
Despite applying for hundreds of jobs, he is still out of work.
尽管他申请了数百个工作，但仍然在失业中。
Despite the power cuts, the hospital continued to function normally.
尽管供电中断，医院继续照常运作。（后接的是个句子）
《牛津高阶英汉双解词典》
She was good at physics despite the fact that she found it boring.
尽管她认为物理枯燥无味，她却学得很好。《牛津高阶英汉双解词典》
Despite the fact that she was wearing a seat belt, she was thrown sharply forward.
尽管她系了安全带，还是被猛然前抛。
She decided to help her husband despite the fact that he had cheated on her.
尽管丈夫对她不忠，她还是决定要帮他。
She told friends she will stand by husband，despite reports that he sent another woman love notes。
她告诉朋友，她会支持她的丈夫，尽管有消息说它的丈夫给其他女性示好。
Despite everything that had happened in the interim, they had remained good friends.
不管在此间所发生的一切，他们还是好朋友。
《牛津高阶英汉双解词典》
Despite his boasts that his children were brilliant, neither of them went to college.
尽管他夸赞他的两个孩子聪明，他们却都没念上大学。
《牛津高阶英汉双解词典》
Despite strong opposition, the ruling party carried the day.
尽管遭到强烈反对，执政党还是获胜了。
Despite his cries, no one came to his assistance.
尽管他喊叫，却没有人来帮助他。
The building work will go ahead, despite protests from local residents.
尽管当地居民反对，建筑工程将照样进行。
The proposal will go ahead despite strong objections from the public.
尽管公众强烈反对，这项提案仍将付诸实施。
Despite the threat of war, people went about their business as usual.
虽然战争在即，人们照常忙着自己的事。
Despite the recession the company is confident of further expansion.
尽管经济衰退，公司对进一步扩展仍充满信心。
Their catering business remained strong despite the recession.
尽管出现经济衰退，他们的酒席承办业仍然景气。
Despite signs of an improvement in the economy, there is no room for complacency.
尽管在经济方面有改善的迹象，但仍不容自满。
Despite our attempts to break it, the lock would not yield.
这把锁我们砸也砸不开。
People were swimming in the ocean despite the hurricane warning.
尽管有飓风警报，人们仍然在大海里游泳。
Despite our disagreements, we have been able to find some common ground.
尽管我们存在分歧，但仍能找到一些共同点。
Aid workers remain in the area despite continuous sniping.
尽管冷枪不断，但救援人员仍然留在这一地区。
Despite being a big star, she's very approachable.
她虽然是个大明星，却非常平易近人。
Despite her ordeal, she seems to have suffered no ill effects.
她尽管备受磨难，但好像并未受到不利影响。
Despite the crudity of their methods and equipment, the experiment was a considerable success. 尽管他们的方法和设备较为粗陋，那次实验却相当成功。
Despite months of discussion the negotiations remained deadlocked.
尽管已讨论数月，谈判仍僵持不下。
Despite the lateness of the hour, the children were not in bed.
尽管已是深夜，孩子们仍未就寝。
Despite her handicap, Jane is able to hold down a full-time job.
简尽管有生理缺陷，却能够保住一份全职工作。
Unemployment seems to be rising, despite repeated assurances to the contrary.
尽管反复担保减少失业，失业率看来却在上升。
Despite his six years in politics, he was still regarded by many as the new kid on the block.
他已经从政六年，但很多人仍把他视为初出茅庐。
despite和in spite of是同义词，但是in spite of语气较强。
in spite of sth
不管；尽管
if you say that sb did sth in spite of a fact, you mean it is surprising that that fact did not prevent them from doing it
I went out in spite of the rain.尽管下雨，我仍然外出。（in spite of介词短语）
In spite of the rain, the game went on.
尽管下着雨，比赛仍在继续。
She loved her husband in spite of the fact that he earned less money than her.
虽然丈夫没有自己赚钱多，她仍然爱着他。
In spite of his age, he still leads an active life.
尽管年事已高，他依旧过着一种忙碌的生活。
In spite of his age，he still leads an active life。
尽管他年事已高，他仍然保持着有激情的生活态度。
She is still very active, in spite of her advancing years.
她尽管年事渐高，仍然十分活跃。
In spite of what happened, he never lost the will to live.
尽管如此遭遇，他从未丧失活下去的意志。《牛津高阶英汉双解词典》
They went swimming in spite of all the danger signs.
他们无视所有那些危险水域告示牌，还是去游泳了。
English became the official language for business in spite of the fact that the population was largely Chinese.
虽然当地居民主要是中国人，英语却成了商业上正式使用的语言。
Josef Krips at the State Opera hired her in spite of the fact that she had never sung on stage.
尽管她从未在舞台上演唱过，国家歌剧院的约瑟夫·克里普斯还是聘用了她。
They fell in love in spite of the language barrier.
尽管有语言障碍，他们还是相爱了。
They went swimming in spite of all the danger signs.
他们无视所有那些危险水域告示牌，还是去游泳了。
The Derby will be run in spite of the bad weather.
尽管天气恶劣，德比马赛仍将举行。
In spite of their quarrel, they remain the best of friends.
尽管有过争吵，他们仍是最好的朋友。
They are firm friends in spite of temperamental differences.
他们尽管性格不同，但仍然友情甚笃。
In spite of his disappointment, he managed a weak smile.
尽管他很失望，他还是勉强露出一丝淡淡的微笑。
In spite of many defeats, they still had plenty of fight left in them.
他们尽管多次失败，但仍然斗志昂扬。
In spite of the awkward questions the minister never let his guard fall for a moment.
尽管遇到的是些令人尴尬的问题，部长却没有丝毫的失误。
They duly arrived at 9.30 in spite of torrential rain.
尽管下着倾盆大雨，他们仍在9:30准时到达了。
In spite of the travelling and the late night, she did not feel tired.
尽管旅途劳顿，而且睡得很晚，她并没觉得累。
In spite of great peril, I have survived.
虽然处境非常危险，我还是挺过来了。
In spite of her hostility, she was attracted to him.
尽管自己心存敌意，她还是为他所吸引。
In spite of his otherwise excellent vision, he found he was colour-blind.
尽管他视力很好，他却发现自己是个色盲。
He intends to try to leave the country, in spite of a government order cancelling his passport.
尽管政府已经下令吊销他的护照，他还是试图要离开该国。
Their love of life comes in spite of, almost in defiance of, considerable hardship.
尽管面临众多的艰难困苦，他们还是几乎义无反顾地表现出了对生活的热爱。
In spite of the recession, profits have galloped ahead.
尽管还处于萧条期，利润却迅猛增长。
They saw their bills rising steadily, in spite of superhuman efforts to save water.
尽管他们已想方设法节约用水，水费仍旧在稳步上升。
In spite of a dismal record at school, she narrowly squeaked into design school.
尽管在学校的成绩很糟糕，她还是勉强进入了设计学校。
In spite of my outward calm I was very shaken
我外表看似镇定，实则吓得不轻。
He survived in spite of suffering grievous injuries.
尽管身受重伤，他还是活下来了。
They are both very cheerful in spite of their colds.
他们俩虽然感冒了，可都兴高采烈的。
In spite of the extremity of her seclusion she was sane
尽管完全与世隔绝，她依然心智健全。
I wouldn't trust them in spite of all their la-di-da manners.
尽管他们处处显得很高雅的样子，我还是不相信他们。
最后，补充说明：
in spite of yourself
不由自主地
if you do sth in spite of yourself , you do it although you did not intend or expect to
She was deeply moved and in spite of herself could not help showing it.
她被深深地打动了，禁不住为之动容。
The blunt comment made Richard laugh in spite of himself.
这番率直的话让理查德不由自主地大笑起来。
He fell asleep, in spite of himself.
他还是不由得睡着了。
