什么是alk融合,alk突变和alk融合是不同的概念

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田攀文 教授

四川大学华西医院

医学博士、主任医师、博士生导师

四川大学华西医院呼吸与危重症医学科/肺癌中心医疗组长

四川省学术与技术带头人后备人选

中国抗癌协会肺癌专业委员会青年委员

中国医师协会临床精准医疗委员会青年委员

四川省抗癌协会肿瘤呼吸病学专委会副主任委员

四川省医师协会呼吸医师分会青委会副主任委员

获国家科技进步奖二等奖,四川省科技进步奖一等奖

主持国家自然科学基金面上项目、四川省科技厅重点项目等

参考文献

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[2].中国临床肿瘤学会(CSCO)原发性肺癌诊疗指南2020

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[13]. Zhang C, et al. J Thorac Oncol. 2019 Apr;14(4):726-731.

[14]. Shaw AT, et al. N Engl J Med 2014 27; 370(13): 1189-97.

[15]. Wen-Zhao Zhong, et al. 2021 WCLC Abstract WS06.03

[16]. Wen-Zhao Zhong et al. ournal of Thoracic Oncology Vol. 15 No. 6:e95-e99

[17]. Solomon, et al. Abstract TPS8569.

[18].Dziadziuszko R, Mok T, Peters S, et al. Blood first assay screening trial (BFAST) in treatment-naive advanced or metastatic nsclc: Initial results of the phase 2 ALK-positive cohort[J]. Journal of Thoracic Oncology, 2021.

[19].Christopoulos P, Endris V, Bozorgmehr F, et al. EML4‐ALK fusion variant V3 is a high‐risk feature conferring accelerated metastatic spread, early treatment failure and worse overall survival in ALK non‐small cell lung cancer[J]. International Journal of Cancer, 2018, 142(12): 2589-2598.

[20].Yoshida T, Oya Y, Tanaka K, et al. Differential crizotinib response duration among ALK fusion variants in ALK-positive non–small-cell lung cancer[J]. Journal of Clinical Oncology, 2016, 34(28): 3383-3389.

[21].Camidge D R, Niu H, Kim H R, et al. Correlation of baseline molecular and clinical variables with ALK inhibitor efficacy in ALTA-1L[J]. Journal of Clinical Oncology, 2020, 38(15_suppl): 9517.

[22].Cha Y J, Kim H R, Shim H S. Clinical outcomes in ALK-rearranged lung adenocarcinomas according to ALK fusion variants[J]. Journal of Translational Medicine, 2016, 14(1): 1-10.

[23].Camidge DR, Kim HR, Ahn MJ et al. Brigatinib Versus Crizotinib in Advanced ALK Inhibitor-Naive ALK-Positive Non-Small Cell Lung Cancer: Second Interim Analysis of the Phase III ALTA-1L Trial. J Clin Oncol. 2020 Nov 1;38(31):3592-3603.

[24]. Azusa Tanimoto, Shingo Matsumoto, Shinji Takeuchi et al.Proteasome Inhibition Overcomes ALK-TKI Resistance in ALK-Rearranged/ TP53-Mutant NSCLC via Noxa Expression. Clin Cancer Res. 2021 Mar 1;27(5):1410-1420.

[25]. Li M, Tang Q, Chen S, et al. A novel HIP1-ALK fusion variant in lung adenocarcinoma showing resistance to Crizotinib[J]. Lung Cancer, 2021, 151: 98-100.

[26].Wei Peng, Si Li, Lijian Li, et al. A Novel LINC00478/LINC01549 Intergenic Region-

ALK Fusion Responded Well to Alectinib in a Patient With Lung Adenocarcinoma. JTO Clin Res Rep. 2020 Oct 17;2(1):100112

[27].Lirong Liu, Fangfang Hou, Yufeng Liu et al. A Case of Lung Adenocarcinoma Response to Alectinib Harboring a Rare EML4-ALK Variant, Exon 6 of EML4 Fused to Exon 18 of ALK. J Natl Compr Canc Netw. 2021 Nov 11;1-5.

[28]. 2021 AACR

[29].NATURE COMMUNICATIONS | (2021) 12:1261 |

[30].National Comprehensive Cancer Network, NCCN Guidelines Non-Small Cell Lung Cancer (Version 6) 2018. 2.Socinski MA, et al. ASCO 2018 Abstract 9002.

[31].Clin Cancer Res. 2020 Feb 21.

*此文仅用于向医学人士提供科学信息,不代表本平台观点

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